Through effective surveillance: the case of diphtheria in a rural district of maharashtra, india revati k phalkeyemail author, rajesh v bhosale, abhijeet p joshi, sushil s wakchoure, muralidhar p tambe, pradip awate and michael marx bmc public health201313:317 https://doiorg/101186/1471-2458-13-317. Assessing diphtheria and tetanus antibody levels in a population of healthy children: a cross-sectional study research article: observational study numerous papers evaluating the effectiveness of particular vaccines are available, but the data are mostly found in clinical trials performed for vaccine manufacturers and. 1clinical department, serum institute of india ltd, 212/2, hadapsar, pune 411028, india 2medical department, serum institute of india research foundation, pune 411028, india 3quality control department, serum institute of india ltd, 212/2, hadapsar, pune 411028, india received 10 october 2011. Corynebacterium diphtheriae is commonly isolated from cutaneous skin lesions in the northern territory of australia we prospectively assessed 32 recent isolates from infected skin lesions, in addition to reviewing 192 isolates collected over 5 years for toxin status no isolates carried the toxin gene toxigenic c. Explore the latest articles, projects, and questions and answers in diphtheria toxin, and find diphtheria toxin experts. Sigma-aldrich offers sigma-d0564, diphtheria toxin from corynebacterium diphtheriae for your research needs find product reconstitution each vial, when reconstituted to 05 ml with sterile distilled water, contains ~1 mg of diphtheria toxin in 001 m tris and 0001 m na2edta, ph 75 peer-reviewed papers.
Sanofi pasteur for assistance with data analysis and manuscript preparation, and timothy voloshen phd for performing serology analyses research paper safety and immunogenicity of a pentavalent combination vaccine (diphtheria, tetanus, acellular pertussis, polio, and haemophilus influenzae type b conjugate). In western countries, nontoxigenic corynebacterium diphtheriae is known to cause skin and soft tissue infections (ssis), upper respiratory tract ethical approval was given at an institutional level in accordance with the national health and medical research council guidelines for low risk human research. Diphtheria is a disease caused by a bacterium, corynebacterium diphtheriae, that usually affects the tonsils, throat, nose and/or skin it is passed from person to person by droplet transmission, usually by breathing in diphtheria bacteria after an infected person has coughed or sneezed although diphtheria disease is rare in. Diphtheria is a kind of infection which is instigated by a special type of bacterium called as corynebacterium diphtheriae the disease derives its name from.
Diphtheria is a paradigm of the toxigenic infectious diseases in 1883, klebs demonstrated that corynebacterium diphtheriae was the agent of diphtheria one year later, loeffler found that the organism could only be cultured from the nasopharyngeal cavity, and postulated that the damage to internal organs resulted from a. Research paper immune modulation by adjuvants combined with diphtheria toxoid administered topically in balb/c mice after microneedle array pretreatment z ding,1,3 e van riet,1 s romeijn,1 g f a kersten,2 w jiskoot, 1 and j a bouwstra1,4 received december 26, 2008 accepted march.
Diphtheria manifests as either an upper respiratory tract or cutaneous infection and is caused by the aerobic gram-positive bacteria, corynebacterium elek test detects the development of an immunoprecipitin band on a filter paper impregnated with antitoxin and then is laid over an agar culture of the. Position paper (august 2017 update) original english and french versions pdf, 526kb · references pdf, 287kb · diphtheria evidence to recommendations table pdf, 194kb · grade table duration of protection conferred by diphtheria vaccination pdf, 130kb · summary of who position paper on diphtheria vaccines,. Articles clinical descriptions of diphtheria appeared in hippocratic writings, but the illness was not clearly differentiated from other upper respiratory disease until clinician-pathologist pierre bretonneau first described its unique clinical characteristics [1, 2] diphtheria is an acute, communicable disease.